Pipeline

At GSK, our pipeline is focused on unlocking the science of the immune system, human genetics, and advanced technologies to develop vaccines and specialty medicines.

Our products in development progress through three stages: phase I, phase II, and phase III/registrational. Each of these phases allows us to assess the safety and efficacy of our investigational products to eventually provide data to support applications for regulatory approval.

DISEASE STATES

Results
COVID-19
Phase 1

mRNA COVID-19 2nd Gen vaccine candidate GSK4396687*

Safety, reactogenicity, and immunogenicity against SARS-CoV-2 in seropositive adults 18 years of age and older

COVID-19
Phase 2

mRNA COVID-19 2nd Gen vaccine candidate GSK4396687*

Safety and immune response in healthy adults

iNTS (S. Typhimurium + S. Enteritidis)
Phase 1/2

iNTS (Invasive non-typhoidal salmonella prophylaxis) vaccine candidate GSK4077164*

Safety, reactogenicity, and immunogenicity in European (Stage 1) and African (Stage 2) adults 18–50 years of age

Meningococcal Disease
Phase 3

Meningococcal Group B Vaccine GSK3536829*

Safety and immunogenicity of Bexsero administered concomitantly with Menveo to healthy infants 

Safety and immunogenicity of 13-valent pneumococcal vaccine and Bexsero when administered concomitantly with routine infant vaccines in healthy infants 6 weeks through 12 weeks of age

mRNA Influenza
Phase 1

mRNA Influenza vaccine candidate GSK4382276*

Safety and immunogenicity in healthy adults 18-55 and 65 years and older

Safety, reactogenicity, and immunogenicity in healthy adults 18-45 years and 60-80 years of age

mRNA Influenza
Phase 1/2

mRNA Influenza vaccine candidate GSK4382276*

Reactogenicity, safety, and immunogenicity in healthy adults aged 18-50 years (Phase 1) and 18-85 years of age (Phase 2)

Pandemic mRNA H5 Influenza vaccine candidate GSK5536522*

Safety, reactogenicity, and immunogenicity, dose-finding and dose-confirmation of the flu pandemic mRNA vaccine against pandemic H5N1 in healthy adults 18–85 years

mRNA Influenza
Phase 2

mRNA Influenza vaccine candidate GSK4382276*

Dose-finding study to evaluate safety and immunogenicity in adults 18 years of age and older 

Reactogenicity, safety, and immune response in healthy adults age 18 years and older

S. Pneumoniae
Phase 1

Pneumococcal 24-valent vaccine candidate for pediatrics GSK5101955*

Safety, tolerability and immunogenicity in a dose-escalation study in toddlers 12 to 15 months of age 

Pneumococcal 30plus-valent vaccine candidate for adults GSK5459248*

Safety and immunogenicity in adults 50–64 years of age

S. Pneumoniae
Phase 2

Pneumococcal 24-valent vaccine candidate for pediatrics GSK5101955*

Safety, tolerability and immunogenicity of 3 different doses compared with PCV13 and PCV20 in healthy infants

Varicella
Phase 2

Varicella New Seed vaccine candidate GSK4178116

Immune response and safety in healthy children 12 to 15 months of age

Varicella
Phase 3

Varicella New Seed vaccine candidate GSK4178116

Immune response and safety when given as a second dose to healthy children (12–15 months of age) 3 months after given a first dose

Respiratory Syncytial Virus
Phase 2

Respiratory Syncytial Virus Vaccine, Adjuvanted

Immunogenicity and safety in adults 18 years and older with lung or kidney transplant compared to healthy adults

Respiratory Syncytial Virus
Phase 3

Respiratory Syncytial Virus Vaccine, Adjuvanted    

Extension and crossover study to evaluate immunogenicity and safety of different revaccination schedules and persistence of a single dose in adults 60 years and older

Immunogenicity in adults 18-49 years old at increased risk for RSV-LRTD compared to adults 60 years and older

MMRV New Seed
Phase 2

Measles, Mumps, Rubella, Varicella New Seed vaccine candidate GSK4406371

Immunogenicity and safety of various potencies in healthy children 4 to 6 years of age

Influenza and COVID-19 Combination
Phase 1/2

mRNA Seasonal Flu/COVID-19 vaccine candidate GSK5475152*

Reactogenicity, safety, and immune response in adults age 18 years and older

Uropathogenic Escherichia coli (UPEC)
Phase 1/2

UPEC adjuvanted recombinant subunit vaccine candidate GSK5102188

Safety, reactogenicity, and immune response in adults afted 18–64 years (Part 1) and preliminary efficacy in females 18–64 years (Part 2)    

Group A Streptococcus pyogenes
Phase 1

Group A streptococcus pyogenes vaccine candidate GSK4424989*

Safety, reactogenicity, and immunogenicity of various doses and formulations in adults 18–25 years of age

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Disclaimer

This document contains information for healthcare providers and is intended solely for educational purposes. This display includes ongoing clinical trials for both approved and investigational compounds.

Some agents are approved in select indications. Inclusion in this display does not imply regulatory approval for these compounds or all indications. Information about all trials can be found at www.clinicaltrials.gov.

 

Footnotes

*In-license or other alliance relationship with third party.