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Click here to learn more about uncomplicated and complicated UTIs

UTI definitions were reclassified in an updated clinical practice guideline published by the IDSA in July 20255

Old Classifications

  • Uncomplicated UTI:
    Acute cystitis in afebrile nonpregnant premenopausal women with no diabetes and no urologic abnormalities
  • Acute Pyelonephritis:
    Acute kidney infection in women otherwise meeting the definition of uncomplicated UTI above
  • Complicated UTI:
    All other UTIs

New Classifications

  • Uncomplicated UTI:
    Infection confined to the bladder in afebrile women or men
  • Complicated UTI:
    Infection beyond the bladder in women and men
    • Pyelonephritis
    • Febrile or bacteremic UTI
    • Cather-associated (CAUTI)
    • Prostatitis (not covered by these guidelines)

References

  1. Advani SD, et al. Antimicrob Steward Healthc Epidemiol. 2025;5(1):e143.
  2. Medina M., Castilo-Pino E. Ther Adv Urol. 2019 May 2:11:1756287219832172.
  3. Lee HS, Le J. Urinary Tract Infections. 2018. https://www.accp.com/docs/bookstore/psap/p2018b1_sample.pdf.
  4. Foxman B, Brown P. Infect Dis Clin N Am. 2003;17(2):227–241.
  5. IDSA. Complicated Urinary Tract Infections (cUTI): Clinical Guidelines for Treatment and Management. Accessed April 2026.