RSV, Virus

Risk Factors and Clinical Burden of RSV in Older Adults


While RSV-related infections usually present as mild, cold-like symptoms in adults, some cases may lead to more serious complications, hospitalization, and death, particularly in older adults and adults with underlying conditions1

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Risk Factors

Risk factors for severe RSV disease in adults include:

Age and underlying medical conditions among adults hospitalized with RSV

In a large prospective study conducted in two regions in NY across 3 RSV seasons between 2017-2020 (N = 1099 hospitalized RSV cases):2


Incidence of RSV Infection in Hospitalized Adults2

RSV, Graph, Hospitalization

This graph was independently created for GSK from the original data

Hospitalization rates for RSV were higher for older adults (≥65 years) with certain underlying medical conditions2

RSV, Graph, Hospitalization

*Ratio of rate among people with each comorbidity vs those without it, in the surveillance area population. Range shown are the Incidence Rate Ratios observed in Rochester and NYC; †Not statistically significant ‡CHF patient population is ≥60 years of age, CAD: coronary artery disease; CHF: congestive heart failure; COPD: chronic obstructive pulmonary disease

Burden of Disease

RSV and Influenza Burden of Disease Among Adults ≥65 years of age in the US

RSV, Complications, Adults, Graph

This graph was independently created for GSK from the original data

Economic Burden of RSV in Older Adults

RSV, Hospital


CAD, coronary artery disease; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; NYC, New York City; RSV, respiratory syncytial virus


  1. CDC, 2020. RSV in older adults and adults with chronic medical conditions. Accessed July 2022.
  2. Branche AR et al. Clin Infect Dis. 2022 Mar 23;74(6):1004-1011. doi: 10.1093/cid/ciab595
  3. Belongia EA et al. Open Forum Infect Dis 2018;27;5:ofy316.
  4. Falsey AR et al. N Engl J Med 2005;352:1749–1759.
  5. June 2022 ACIP presentation on "RSV in adults". Available at:
  6. Estimated Influenza Disease Burden 2015-2016 through 2019-2020, CDC (2022):